AntiVirus exclusions for MS SharePoint 2010
Foundation and SharePoint Server
Drive:\Program Files\Common Files\Microsoft Shared\Web Server Extensions
If you do not want to exclude the whole "Web Server Extensions" folder from antivirus scanning, you can exclude only the following two folders:
Drive:\Program Files\Common Files\Microsoft Shared\Web Server Extensions\14\Logs
Drive:\Program Files\Common Files\Microsoft Shared\Web Server Extensions\14\Data\Applications
Drive:\Windows\Microsoft.NET\Framework64\v2.0.50727\Temporary ASP.NET Files
Drive: \Users\service account\AppData\Local\Temp\WebTempDir
Drive\ProgramData\Microsoft\SharePoint\
Drive\Users\the account that the search service is running as\AppData\Local\Temp
Note The search account creates a folder in the "gthrsvc_spsearch4 Temp" folder to which it periodically needs to write.
Drive:\WINDOWS\system32\LogFiles
On 64 Bit Windows 2008 Server with 64 Bit Product, the location is Drive:\Windows\Syswow64\LogFiles
Note If you use a specific account for SharePoint services or application pools identities, you may also have to exclude the following folders:
Drive:\Users\ServiceAccount\AppData\Local\Temp
Drive:\Users\Default\AppData\Local\Temp
SharePoint Server
You may have to configure the antivirus software to exclude the "Drive:\Program Files\Microsoft Office Servers" folder from antivirus scanning for SharePoint Server 2010. If you do not want to exclude the whole "Microsoft Office Servers" folder from antivirus scanning, you can exclude only the following folders: Drive:\Program Files\Microsoft Office Servers\14.0\Data.
(This folder is used for the indexing process. If the Index files are configured to reside in a different folder, you also have to exclude that location.)
Drive:\Program Files\Microsoft Office Servers\14.0\Logs
Drive:\Program Files\Microsoft Office Servers\14.0\Bin
Drive:\Program Files\Microsoft Office Servers\14.0\Synchronization Service
Any location you chose to store Disk-based BLOB cache. For example: C:\blobcache For more information on BLOB cache, see: http://technet.microsoft.com/en-us/library/ee424404.aspx#Section1
Full list of exclusions for other SharePoint version here : http://support.microsoft.com/kb/952167
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